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Ma R, Agrawal U, Mody N, Vyas SP. Polymer nanotechnology basedMa R, Agrawal U, Mody N, Vyas SP. Polymer nanotechnology based approaches in mucosal vaccine delivery: challenges andtion to the strong but potentially vulnerable, hence increasing sense of security and cohesiveness. Whatever the impetus for destigmatization might be, the results of the destigmatization campaigns are far fro
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Less potent, K10 adhesin [33]. Complementation of Newman DclfB with pCU1:clfB restored adherence to HLor (Figure S2). These data show that loricrin is a ligand for ClfB. To establish if ClfB alone can promote bacterial adhesion to immobilized loricrin, adhesion assays were performed using L. lactis MG1363 carrying a plasmid that expressed ClfB (pKS80:clfB) [40] and compared to L. lactis carrying t
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Ulum stress response". Mouse homologs of genes differentially regulated by BaP in Oikopleura are indicated on the pathway map by thermometer like symbols (encircled for clarity). See Additional file 5 for detailed figure legend.6). One of the BaP-induced key transcription factors, JunD is a functional component of the AP-1 transcription factor complex. AP-1 is one of the top ranked transcription f
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ST collections did not reveal a candidate ortholog for AhR. HMM searches for PAS domain proteins in predicted Oikopleura protein database and BLAST searches using various bHLH-PAS domain protein sequences of vertebrates and invertebrates identified three bHLH-PAS domain proteins in Oikopleura. One PAS domain protein identified (accession: CBY20245) is a potassium voltage-gated channel family like
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630 genes, with 166 genes up-regulated and 464 genes down-regulated (Additional file 4). Genes involved in the xenobiotic defense system in vertebrates were part of the list, including biotransformation enzyme genes such as CYP2-like-11 gene (CBY24358), conjugating enzyme genes such as GSTa, and some ABC transporters and solute carrier proteins (Additional file 4). Superoxide dismutase and many AB
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Lycolysis/Gluconeogenesis Hypertrophic cardiomyopathy (HCM) Focal adhesion Dilated cardiomyopathy Alzheimer's disease Huntington's disease Oxidative phosphorylation Parkinson's disease Propanoate metabolism Citrate cycle (TCA cycle) Count PValue Benjamini FDR 12 9 11 9 10 11 17 11 16 16 13 13 6 6 8.28E-05 1.15E-04 2.31E-04 3.19E-04 3.74E-04 4.27E-04 8.40E-04 8.86E-04 9.98E-04 1.06E-03 1.21E-03 1.4
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Imensional gel analysis: two-dimensional difference gel electrophoresis incorporating a pooled internal standard. Proteomics 2003, 3:36-44. Freeman WM, Brebner K, Amara SG, Reed MS, Pohl J, Phillips AG: Distinct proteomic profiles of amphetamine self-administration transitional states. Pharmacogenomics Journal 2005, 5:203-214. Freeman WM, Hemby SE: Proteomics for protein expression profiling in ne
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Sis of the equilibrium binding data the dissociation constant (KD) of the interaction between rClfB201?42 and loricrin was determined to be 4.3361.1 mM. Similar experiments were carried out with MLor (Figure 2B) which had a slightly lower affinity for rClfB201?42 (KD = 15.6663.4 mM). The affinity of rClfB201?42 for GST-tagged proteins corresponding to high affinity binding sites in human (Figure 2